RBR E3‐ligases at work
نویسندگان
چکیده
منابع مشابه
RBR E3-ligases at work.
The RING-in-between-RING (RBR) E3s are a curious family of ubiquitin E3-ligases, whose mechanism of action is unusual in several ways. Their activities are auto-inhibited, causing a requirement for activation by protein-protein interactions or posttranslational modifications. They catalyse ubiquitin conjugation by a concerted RING/HECT-like mechanism in which the RING1 domain facilitates E2-dis...
متن کاملArabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
Post-embryonic growth in plants depends on the continuous supply of undifferentiated cells within meristems. Proliferating cells maintain their competence for division by active repression of differentiation and the associated endocycle entry. We show by upregulation and downregulation of E2FA that it is required for maintaining proliferation, as well as for endocycle entry. While E2FB-RBR1 (re...
متن کاملRBR: library-less repeat detection for ESTs
MOTIVATION Repeat sequences in ESTs are a source of problems, in particular for clustering. ESTs are therefore commonly masked against a library of known repeats. High quality repeat libraries are available for the widely studied organisms, but for most other organisms the lack of such libraries is likely to compromise the quality of EST analysis. RESULTS We present a fast, flexible and libra...
متن کاملRBR E3 ubiquitin ligases: new structures, new insights, new questions
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes. This unique family of E3 ligases includes parkin, whose dysfunction is linked to the pathogenesis of early-onset Parkinson's disease, and HOIP (HOIL-1-interacting protein) and HOIL-1 (haem-oxidized IRP2 ubiquitin ligase 1), m...
متن کاملFixed-term work and violence at work.
OBJECTIVES This study investigated the effect of a fixed-term job contract on encounters of violence at work. We assumed that fixed-term employees encountered more violence or threats of violence at their work than permanent employees. METHODS This study is based on 3 large statistical data sets: (a) the Work and Health surveys carried out by the Finnish Institute of Occupational Health in 19...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2014
ISSN: 1469-221X,1469-3178
DOI: 10.1002/embr.201338166